Venture Guides is an early-stage venture capital firm founded in 2023 and headquartered in Boston, Massachusetts. The firm specializes in backing infrastructure software companies, including cloud, security, AI, and data, employing a unique team-based, data-informed investment model. They provide active guidance and hands-on support to founders in areas like go-to-market strategy, recruiting, finance, and business operations. Venture Guides invests primarily in Pre-seed, Seed, Seed+, and Series A stages, with check sizes typically ranging from $500,000 to $5 million. They maintain a concentrated portfolio of 15-20 companies, fostering a collaborative environment, including co-locating portfolio companies in their Boston headquarters. The firm recently closed its Fund II at $262.5 million in April 2025, demonstrating strong investor confidence.